The Mark Hotel Domus is located in close proximity to some of the city's major attractions. The Wilhelmshohe Castle Park is located not too far from this Kassel hotel. Other attractions located within the city include the museums and the shopping and commercial district which is located not too far from the premises. The Mark Hotel Domus is located near the city's main railway station. There are major roadways that traverse the city and which provide another method of reaching Kassel.

Guests of the Mark Hotel Domus will find that their rooms are provided with satellite television service, a desk suitable for working, a minibar and direct-dial telephone service. There is also wireless Internet connectivity available upon arrangement.

The Mark Hotel Domus contains a restaurant which serves a breakfast buffet every morning. There is a bar open in the evenings which provides a place to relax and enjoy a drink. The hotel desk is open around the clock and the lobby is stocked with newspapers.